Pub. Date : 2018 Mar
PMID : 28771713
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EPA blocks TNF-alpha-induced inhibition of sugar uptake in Caco-2 cells via GPR120 and AMPK. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 2 | The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-alpha (TNF-alpha) on sugar transport, and identify the intracellular signaling pathways involved. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 3 | The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-alpha (TNF-alpha) on sugar transport, and identify the intracellular signaling pathways involved. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 4 | The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-alpha (TNF-alpha) on sugar transport, and identify the intracellular signaling pathways involved. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 5 | The aim of the present work was to investigate in Caco-2 cells whether eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, could block the inhibitory effect of tumor necrosis factor-alpha (TNF-alpha) on sugar transport, and identify the intracellular signaling pathways involved. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 6 | Interestingly, the AMPK inhibitor, Compound C, abolished the ability of EPA to prevent TNF-alpha-induced reduction of sugar uptake and transporter expression. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 7 | The GPR120 antagonist, AH7614, also blocked the preventive effect of EPA on TNF-alpha-induced decrease of alphaMG uptake and AMPK phosphorylation. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |
| 8 | EPA prevents the inhibitory effect of TNF-alpha through the involvement of GPR120 and AMPK activation. | Eicosapentaenoic Acid | tumor necrosis factor | Homo sapiens |