Title : Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress.

Pub. Date : 2017 Aug 3

PMID : 28771227






1 Functional Relationships(s)
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1 In addition, Klotho reduced Tac-induced mitochondrial dysfunction and decreased mitochondrial reactive oxygen species production, and these effects were enhanced by blocking PI3K activity with LY294002. Reactive Oxygen Species klotho Homo sapiens