Pub. Date : 2017 Sep
PMID : 28759712
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol induces inducible COX-2-dependent antiproliferation via integrin alphav beta3 . | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Hormones inhibit resveratrol-stimulated phosphorylation of p53 on Ser15, resveratrol-induced nuclear COX-2 accumulation, and formation of p53-COX-2 nuclear complexes. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Subsequently, hormones impair resveratrol-induced COX-2-/p53-dependent gene expression. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Results suggest that nonpeptide hormones inhibit resveratrol-induced antiproliferation in cancer cells downstream of the interaction between ligand and receptor and ERK1/2 activation to interfere with nuclear COX-2 accumulation. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |