Pub. Date : 2017 Dec
PMID : 28756872
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor alpha. | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 2 | We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-alpha (RARalpha) in a murine model of HIV-associated nephropathy. | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 3 | We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-alpha (RARalpha) in a murine model of HIV-associated nephropathy. | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 4 | RA treatment markedly improved renal function and reduced the number of crescentic lesions in nephritic wild-type mice, while this protection was largely lost in mice with podocyte-specific ablation of Rara (Pod-Rara knockout). | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 5 | RA treatment markedly improved renal function and reduced the number of crescentic lesions in nephritic wild-type mice, while this protection was largely lost in mice with podocyte-specific ablation of Rara (Pod-Rara knockout). | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 6 | Furthermore, RA suppressed the expression of cell injury, proliferation, and parietal epithelial cell markers in nephritic wild-type mice, all of which were significantly dampened in nephritic Pod-Rara knockout mice. | Tretinoin | retinoic acid receptor, alpha | Mus musculus |
| 7 | Thus, RA attenuates crescentic glomerulonephritis primarily through RARalpha-mediated protection of podocytes and in part through the inhibition of parietal epithelial cell proliferation and induction of their transdifferentiation into podocytes. | Tretinoin | retinoic acid receptor, alpha | Mus musculus |