Pub. Date : 2017 Sep 15
PMID : 28750831
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity. | Amphetamine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | Changes in TH activity, assessed as L-DOPA accumulation and TH phosphorylation levels, were measured in amphetamine treated rats with or without pretreatment with GBR12909. | Amphetamine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | GBR12909, while having no effect on its own, blocked amphetamine-induced elevation of TH activity in dorsal striatum and nucleus accumbens, measured as increased tissue L-DOPA concentration. | Amphetamine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Our findings indicate that other mechanisms than phosphorylation-regulated TH activity changes are responsible for the paradoxical calming effect of amphetamine under conditions of impaired DAT activity. | Amphetamine | tyrosine hydroxylase | Rattus norvegicus |