Title : The effects of cysteamine on dopamine-mediated behaviors: evidence for dopamine-somatostatin interactions in the striatum.

Pub. Date : 1986 Jun

PMID : 2874568






4 Functional Relationships(s)
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1 The effects of prior treatment with cysteamine, a drug which appears to deplete selectively the neuropeptide somatostatin, on apomorphine-induced stereotypy and amphetamine-induced locomotor activity and conditioned place preferences were investigated. Cysteamine somatostatin Homo sapiens
2 Twelve hours following systemic cysteamine injections apomorphine-induced stereotypy was attenuated and striatal somatostatin levels were reduced by half. Cysteamine somatostatin Homo sapiens
3 Direct injections of cysteamine into the nucleus accumbens also decreased the locomotor response to amphetamine, and produced a local reduction in somatostatin levels in the accumbens. Cysteamine somatostatin Homo sapiens
4 Furthermore, it is evident from these results that cysteamine is an important tool with which to study the central actions of somatostatin. Cysteamine somatostatin Homo sapiens