Pub. Date : 2017 Sep 20
PMID : 28731321
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Conjugation Dependent Interaction of Folic Acid with Folate Binding Protein. | Folic Acid | folate receptor alpha | Homo sapiens |
| 2 | Serum proteins play a critical role in the transport, uptake, and efficacy of targeted drug therapies, and here we investigate the interactions between folic acid-polymer conjugates and serum folate binding protein (FBP), the soluble form of the cellular membrane-bound folate receptor. | Folic Acid | folate receptor alpha | Homo sapiens |
| 3 | Serum proteins play a critical role in the transport, uptake, and efficacy of targeted drug therapies, and here we investigate the interactions between folic acid-polymer conjugates and serum folate binding protein (FBP), the soluble form of the cellular membrane-bound folate receptor. | Folic Acid | folate receptor alpha | Homo sapiens |
| 4 | We demonstrate that both choice of polymer and method of ligand conjugation affect the interactions between folic acid-polymer conjugates and serum FBP, resulting in changes in the folic acid-induced protein aggregation process. | Folic Acid | folate receptor alpha | Homo sapiens |
| 5 | We demonstrate that both choice of polymer and method of ligand conjugation affect the interactions between folic acid-polymer conjugates and serum FBP, resulting in changes in the folic acid-induced protein aggregation process. | Folic Acid | folate receptor alpha | Homo sapiens |
| 6 | When poly(amidoamine) dendrimer-folic acid conjugates bound to FBP, the distribution of nanoparticles was preserved. | Folic Acid | folate receptor alpha | Homo sapiens |
| 7 | In contrast, poly(ethylene glycol)-folic acid conjugates demonstrated substantially reduced binding to FBP, did not cause folic acid-induced aggregation, and fully disrupted FBP self-aggregation. | Folic Acid | folate receptor alpha | Homo sapiens |
| 8 | In contrast, poly(ethylene glycol)-folic acid conjugates demonstrated substantially reduced binding to FBP, did not cause folic acid-induced aggregation, and fully disrupted FBP self-aggregation. | Folic Acid | folate receptor alpha | Homo sapiens |
| 9 | Our results suggest that prebinding therapeutic nanocarriers to serum FBP may allow folate-specific metabolic pathways to be exploited for delivery while also affording benefits of utilizing an endogenous protein as a vector. | Folic Acid | folate receptor alpha | Homo sapiens |