Pub. Date : 2017 Sep
PMID : 28715866
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effects of isorhamnetin on N2a cell against endoplasmic reticulum stress-induced injury is mediated by PKCepsilon. | 3-methylquercetin | protein kinase C, epsilon | Mus musculus |
| 2 | This study was to investigate whether Iso can inhibit ERS-induced apoptosis in N2a cells, and the protective effects are involved in PKCepsilon-mediated Ca2+ homeostasis and inhibition of ROS. | 3-methylquercetin | protein kinase C, epsilon | Mus musculus |
| 3 | In addition, Iso can promote PKCepsilon phosphorylation, and epsilonV1-2 (a PKCepsilon inhibitor) drastically attenuated the protective effects of Iso against ERS injury in N2a cells. | 3-methylquercetin | protein kinase C, epsilon | Mus musculus |
| 4 | In addition, Iso can promote PKCepsilon phosphorylation, and epsilonV1-2 (a PKCepsilon inhibitor) drastically attenuated the protective effects of Iso against ERS injury in N2a cells. | 3-methylquercetin | protein kinase C, epsilon | Mus musculus |
| 5 | In conclusion, we firstly demonstrated that Iso can elicit protective effects against ERS injury in N2a cells and these effects are mediated at least in part via PKCepsilon pathway. | 3-methylquercetin | protein kinase C, epsilon | Mus musculus |