Pub. Date : 1986 Mar-Apr
PMID : 2870898
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is likely, therefore, that the mechanism of action of these compounds is the same as that for allylisopropylacetamide (AIA) and related monosubstituted olefins, which are converted by cytochrome P-450 to chemically reactive species which bind covalently to the prosthetic heme moiety of the cytochrome and thereby destroy the enzyme. | Alkenes | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | These findings, together with data from related metabolic studies on AIA, support the view that the efficiency of the initial double bond oxidation reaction determines the extent of cytochrome P-450 destruction during the metabolism of terminal olefins, rather than any subsequent step. | Alkenes | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |