Title : Metabolism of unsaturated derivatives of valproic acid in rat liver microsomes and destruction of cytochrome P-450.

Pub. Date : 1986 Mar-Apr

PMID : 2870898






2 Functional Relationships(s)
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1 It is likely, therefore, that the mechanism of action of these compounds is the same as that for allylisopropylacetamide (AIA) and related monosubstituted olefins, which are converted by cytochrome P-450 to chemically reactive species which bind covalently to the prosthetic heme moiety of the cytochrome and thereby destroy the enzyme. Alkenes cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 These findings, together with data from related metabolic studies on AIA, support the view that the efficiency of the initial double bond oxidation reaction determines the extent of cytochrome P-450 destruction during the metabolism of terminal olefins, rather than any subsequent step. Alkenes cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus