Title : Autophagy-ERK1/2-Involved Disinhibition of Hippocampal Neurons Contributes to the Pre-Synaptic Toxicity Induced by Aβ42 Exposure.

Pub. Date : 2017

PMID : 28697568






3 Functional Relationships(s)
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1 The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens
2 The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens
3 The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens