Title : Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.

Pub. Date : 2017 Oct

PMID : 28687611






1 Functional Relationships(s)
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1 A screening campaign revealed retinol (vitamin A alcohol) and all-trans retinoic acid (vitamin A acid) (RA) as hits that time-dependently (>=24 h) deplete phosphatidylcholine-bound polyunsaturated fatty acids (PUFA-PCs) from NIH-3T3 mouse fibroblasts while inducing Akt activation (EC50 0.1-1 microM). Phosphatidylcholines thymoma viral proto-oncogene 1 Mus musculus