Pub. Date : 2017 Jul 6
PMID : 28684780
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 2 | In addition, our results demonstrate that RA inhibits EGFR and Wnt signaling activation, two pathways involved in NSCLC progression. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 3 | Furthermore, we uncovered a novel mechanism in NSCLC that shows how RA exerts its function; we found that RA-mediated GATA6 activation is necessary for EGFR and Wnt inhibition, thus leading to 1) increased differentiation and 2) loss of proliferation. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 4 | Furthermore, we uncovered a novel mechanism in NSCLC that shows how RA exerts its function; we found that RA-mediated GATA6 activation is necessary for EGFR and Wnt inhibition, thus leading to 1) increased differentiation and 2) loss of proliferation. | Tretinoin | epidermal growth factor receptor | Homo sapiens |