Title : Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways.

Pub. Date : 2017 Sep 1

PMID : 28684419






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Versican is a large chondroitin sulfate-containing, hyaluronic acid-binding proteoglycan present in the extracellular matrix and in ocular vitreous body. Hyaluronic Acid versican Homo sapiens
2 Proteolysis of versican generates a hyaluronan-binding G1 domain. Hyaluronic Acid versican Homo sapiens
3 These data implicate versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic acid-CD44 independent manner that is down-regulated by inhibitors of the JAK/STAT pathway and enhanced by inhibitors of the Src kinase pathway. Hyaluronic Acid versican Homo sapiens