Title : Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades.

Pub. Date : 2018 Feb

PMID : 28681916






4 Functional Relationships(s)
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1 Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades. luteolin-7-glucoside TNF superfamily member 11 Homo sapiens
2 Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades. luteolin-7-glucoside TNF superfamily member 11 Homo sapiens
3 In addition, Luteoloside suppressed RANKL-induced osteoclast differentiation and abrogated bone resorption in a dose-dependent manner. luteolin-7-glucoside TNF superfamily member 11 Homo sapiens
4 Further, we found that the anti-osteoclastic and anti-resorptive actions of Luteoloside are mediated via blocking NFATc1 activity and the attenuation of RANKL-mediated Ca2+ signaling as well as NF-kappaB and MAPK pathways. luteolin-7-glucoside TNF superfamily member 11 Homo sapiens