Title : microRNA-142-3p inhibits apoptosis and inflammation induced by bleomycin through down-regulation of Cox-2 in MLE-12 cells.

Pub. Date : 2017 Jul 3

PMID : 28678919






2 Functional Relationships(s)
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1 Up-regulation of Cox-2 and inactivation of PI3K/AKT/mTOR were found in bleomycin-pretreated cells, while these abnormal regulations were partially abolished by miR-142-3p overexpression and NS-398. Bleomycin thymoma viral proto-oncogene 1 Mus musculus
2 In conclusion, this study demonstrated that miR-142-3p overexpression protected bleomycin-induced injury in lung epithelial MLE-12 cells, possibly via regulating Cox-2 expression and PI3K/AKT/mTOR signaling pathway. Bleomycin thymoma viral proto-oncogene 1 Mus musculus