Pub. Date : 2017 Sep
PMID : 28677768
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thromboxane A2 receptor antagonist SQ29548 suppresses the LPS-induced release of inflammatory cytokines in BV2 microglia cells via suppressing MAPK and NF-kappaB signaling pathways. | SQ 29548 | toll-like receptor 4 | Mus musculus |
| 2 | In the present study, the anti-inflammatory effects of SQ29548 on lipopolysaccharide (LPS)-stimulated BV2 microglial cells and its molecular mechanisms were investigated. | SQ 29548 | toll-like receptor 4 | Mus musculus |
| 3 | In vitro studies demonstrated that SQ29548 inhibited LPS-stimulated BV2 activation and reduced the mRNA expression levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha and inducible NO synthase via inhibition of MAPKs and the NF-kappaB signaling pathway. | SQ 29548 | toll-like receptor 4 | Mus musculus |
| 4 | SQ29548 inhibited the LPS-induced inflammatory response by blocking MAPKs and NF-kappaB activation in BV2 microglial cells. | SQ 29548 | toll-like receptor 4 | Mus musculus |