Pub. Date : 2017 Sep
PMID : 28677722
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enzymes that catalyze the oxidation of retinol to generate atRA, including aldehyde dehydrogenase 1 family (ALDH1)A1, ALDH1A2 and ALDH1A3, exhibit complex expression patterns at different stages of renal development. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | In this study, we provide in vitro evidence to demonstrate that Wilms" tumor 1 (WT1) negatively regulates the expression of the atRA synthetic enzymes, ALDH1A1, ALDH1A2 and ALDH1A3, in the 293 cell line, leading to significant blockage of atRA production. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |