Title : Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice.

Pub. Date : 2017 Jul

PMID : 28676202






5 Functional Relationships(s)
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1 Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. 1-hexacosanol sterol regulatory element binding factor 2 Mus musculus
2 Alternatively, hexacosanol suppressed the nuclear translocation and activation of sterol regulatory element-binding protein-2 (SREBP-2), a key transcription factor in cholesterol biosynthesis. 1-hexacosanol sterol regulatory element binding factor 2 Mus musculus
3 Alternatively, hexacosanol suppressed the nuclear translocation and activation of sterol regulatory element-binding protein-2 (SREBP-2), a key transcription factor in cholesterol biosynthesis. 1-hexacosanol sterol regulatory element binding factor 2 Mus musculus
4 These results collectively suggest that hexacosanol is a major hypocholesterolemic compound in barley sprouts with regulation of AMPK activation and SREBP-2 suppression. 1-hexacosanol sterol regulatory element binding factor 2 Mus musculus
5 In conclusion, hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. 1-hexacosanol sterol regulatory element binding factor 2 Mus musculus