Title : Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer.

Pub. Date : 2017 Oct 15

PMID : 28673807






3 Functional Relationships(s)
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1 Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer. walsuronoid B tumor protein p53 Homo sapiens
2 In addition, ROS induced by walsuronoid B upregulated p53 levels; conversely, p53 stimulated ROS. walsuronoid B tumor protein p53 Homo sapiens
3 In summary, our findings demonstrated that walsuronoid B caused G2/M phase arrest and induced mitochondrial and lysosomal apoptosis through the ROS/p53 signaling pathway in human liver cancer cells in vitro and in vivo. walsuronoid B tumor protein p53 Homo sapiens