Title : Downregulation of P16 promotes cigarette smoke extract-induced vascular smooth muscle cell proliferation via preventing G1/S phase transition.

Pub. Date : 2017 Jul

PMID : 28672917






1 Functional Relationships(s)
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1 Overexpression of P16 inhibited CSE-induced cell proliferation through inducing cell cycle arrest in G1 phase (P<0.001), and led to decreased levels of CDK4 (P<0.01), CDK6 (P<0.01) and p-Rb (P<0.001) in HASMCs. hasmcs cyclin dependent kinase inhibitor 2A Homo sapiens