Pub. Date : 2017 Sep
PMID : 28672279
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1alpha/ATF6 pathway. | beta-elemene | activating transcription factor 6 | Mus musculus |
| 2 | Not only that, beta-elemene could up-regulate ERs-related proteins like PERK, IRE1alpha, ATF6, ATF4, CHOP and down-regulate the Bcl-2 expression. | beta-elemene | activating transcription factor 6 | Mus musculus |
| 3 | More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. | beta-elemene | activating transcription factor 6 | Mus musculus |
| 4 | More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. | beta-elemene | activating transcription factor 6 | Mus musculus |
| 5 | Therefore, the present in vivo and in vitro study revealed that the anti-NSCLC effect of beta-elemene is closely related to the activation of ERs through PERK/IRE1alpha/ATF6 pathway, and this might be beneficial for clinical therapy of NSCLC. | beta-elemene | activating transcription factor 6 | Mus musculus |