Title : Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.

Pub. Date : 1985 Dec

PMID : 2866045






2 Functional Relationships(s)
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1 An increase in ornithine decarboxylase activity, associated with a decrease in the liver S-adenosyl-L-methionine pool, also occurred in normal animals on the first day following a partial hepatectomy and was enhanced by phenobarbital. Phenobarbital ornithine decarboxylase 1 Rattus norvegicus
2 Phenobarbital stimulated polyamine synthesis and cell growth and further prolonged the period of time during which a high ornithine decarboxylase activity and labeling index were present. Phenobarbital ornithine decarboxylase 1 Rattus norvegicus