Pub. Date : 2017 Aug 11
PMID : 28655775
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron. | Heme | heme oxygenase 1 | Homo sapiens |
| 2 | Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)-NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron. | Heme | heme oxygenase 1 | Homo sapiens |
| 3 | In heme-loaded cells, heme prompted HO1-CPR complex formation and decreased the HO1/PCBP2 interaction. | Heme | heme oxygenase 1 | Homo sapiens |
| 4 | In heme-loaded cells, heme prompted HO1-CPR complex formation and decreased the HO1/PCBP2 interaction. | Heme | heme oxygenase 1 | Homo sapiens |
| 5 | In heme-loaded cells, heme prompted HO1-CPR complex formation and decreased the HO1/PCBP2 interaction. | Heme | heme oxygenase 1 | Homo sapiens |
| 6 | In heme-loaded cells, heme prompted HO1-CPR complex formation and decreased the HO1/PCBP2 interaction. | Heme | heme oxygenase 1 | Homo sapiens |
| 7 | Furthermore, in vitro reconstitution experiments with purified recombinant proteins indicated that HO1 could bind to PCBP2 in the presence of heme, whereas loading of PCBP2 with ferrous iron caused PCBP2 to lose its affinity for HO1. | Heme | heme oxygenase 1 | Homo sapiens |