Title : Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

Pub. Date : 2017 Jun 27

PMID : 28653623






1 Functional Relationships(s)
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1 Conversely, expression of R172K mutant IDH2 resulted in increased alpha-ketoglutarate-dependent consumption of NADPH compared to wild-type IDH2 or vector control. NADP isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens