Title : Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE.

Pub. Date : 2017 Oct 15

PMID : 28651842






1 Functional Relationships(s)
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1 These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity. Dinoprostone phospholipase A2 group IVA Homo sapiens