Pub. Date : 2017 Oct 15
PMID : 28651842
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE. | glucuronyl glucosamine glycan sulfate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs). | glucuronyl glucosamine glycan sulfate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs). | glucuronyl glucosamine glycan sulfate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity. | glucuronyl glucosamine glycan sulfate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |