Title : Heat-Labile Enterotoxin-Induced PERK-CHOP Pathway Activation Causes Intestinal Epithelial Cell Apoptosis.

Pub. Date : 2017

PMID : 28642847






3 Functional Relationships(s)
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1 Bax is essential for endoplasmic reticulum (ER) stress-triggered apoptosis, and our RNAi experiments showed that the PERK-eIF2-CHOP pathway and reactive oxygen species (ROS) are also main participants in this process. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
2 LT-induced ROS generation was decreased in CHOP-knockdown HCT-8 cells compared to that in control cells. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
3 Moreover, pretreatment with the ROS inhibitor NAC down-regulated GRP78, CHOP, Bim, and cleaved caspase-3 expression, resulting in a reduction in the apoptosis rate from 36.2 to 20.3% in LT-treated HCT-8 cells. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens