Pub. Date : 2017
PMID : 28642847
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bax is essential for endoplasmic reticulum (ER) stress-triggered apoptosis, and our RNAi experiments showed that the PERK-eIF2-CHOP pathway and reactive oxygen species (ROS) are also main participants in this process. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | LT-induced ROS generation was decreased in CHOP-knockdown HCT-8 cells compared to that in control cells. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Moreover, pretreatment with the ROS inhibitor NAC down-regulated GRP78, CHOP, Bim, and cleaved caspase-3 expression, resulting in a reduction in the apoptosis rate from 36.2 to 20.3% in LT-treated HCT-8 cells. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |