Pub. Date : 2017 Jun 21
PMID : 28637493
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further investigation showed that intracellular ROS induced by 5-FU promoted the expression and activation of NLRP3 inflammasome and increased the production of interleukin (IL)-1beta, which then mediated the chemoresistance. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |
| 2 | CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC. | Reactive Oxygen Species | interleukin 1 beta | Mus musculus |