Title : Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells.

Pub. Date : 2017 Jul 19

PMID : 28636040






1 Functional Relationships(s)
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1 In vitro, all three TLMs became strong inhibitors of the cytosolic (TrxR1) and mitochondrial (TrxR2) isoforms of thioredoxin reductase after enzymatic oxidation with HRP/H2O2 while none of the organic analogues was effective. Hydrogen Peroxide thioredoxin Homo sapiens