Title : Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.

Pub. Date : 2017 Sep 1

PMID : 28633380






2 Functional Relationships(s)
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1 The protein ataxin-3 (ATX3) triggers an amyloid-related neurodegenerative disease when its polyglutamine stretch is expanded beyond a critical threshold. polyglutamine Ataxin-3 homolog Caenorhabditis elegans
2 They also prevented the appearance of ordered side-chain hydrogen bonding in ATX3-Q55, which is the hallmark of polyQ-related amyloids. polyglutamine Ataxin-3 homolog Caenorhabditis elegans