Title : Regulation of hepatic monooxygenases by phenobarbital, 3-methylcholanthrene, and polychlorinated biphenyls in rapid and slow acetylator mice.

Pub. Date : 1985 May-Jun

PMID : 2861996






2 Functional Relationships(s)
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1 The administration of the inducers, phenobarbital or the polychlorinated biphenyl mixture Aroclor 1254, resulted in significant increases in cytochrome P-450 and ethylmorphine N-demethylase activity and minimal changes in benzo(a)pyrene hydroxylase activity in both strains. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
2 The latter strain appeared to be more responsive to the inducing properties of the phenobarbital class of inducers, as reflected in the inducibility of cytochrome P-450 and the associated enzymic activities in the liver. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus