Title : Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin.

Pub. Date : 2018 Mar

PMID : 28617100






1 Functional Relationships(s)
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1 Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20. Histidine acetylcholinesterase (Cartwright blood group) Homo sapiens