Title : Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.

Pub. Date : 2017 Jun 14

PMID : 28615362






2 Functional Relationships(s)
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1 We report that potent inhibitors, such as AD80 or ponatinib, that stably bind in the DFG-out conformation of RET may overcome these limitations and selectively kill RET-rearranged tumors. ponatinib ret proto-oncogene Homo sapiens
2 We report that potent inhibitors, such as AD80 or ponatinib, that stably bind in the DFG-out conformation of RET may overcome these limitations and selectively kill RET-rearranged tumors. ponatinib ret proto-oncogene Homo sapiens