Title : The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks.

Pub. Date : 2017 Oct

PMID : 28611105






2 Functional Relationships(s)
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1 Then, we show that despite being more cytotoxic, F14512 is less efficient than etoposide at producing TOP2alpha cleavage-complex (TOP2alphacc) in cells. Etoposide DNA topoisomerase II alpha Homo sapiens
2 Finally, we report that compared with TOP2alphacc mediated by etoposide, those generated by F14512 persist longer in the genome, are not dependent on TDP2 for cleaning break ends from TOP2alpha, are channeled to a larger extent to resection-based repair processes relying on CtIP and BRCA1 and promote RAD51 recruitment to damaged chromatin. Etoposide DNA topoisomerase II alpha Homo sapiens