Pub. Date : 2017 Sep
PMID : 28609310
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockade of GLUT1 by WZB117 resensitizes breast cancer cells to adriamycin. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 2 | In the present study, we explored whether inhibiting the glucose transporter 1 (GLUT1) could restore the activity of adriamycin in breast cancer cell line MCF-7 resistant to adriamycin and the possible underlying mechanisms. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 3 | In the present study, we explored whether inhibiting the glucose transporter 1 (GLUT1) could restore the activity of adriamycin in breast cancer cell line MCF-7 resistant to adriamycin and the possible underlying mechanisms. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 4 | In the present study, we explored whether inhibiting the glucose transporter 1 (GLUT1) could restore the activity of adriamycin in breast cancer cell line MCF-7 resistant to adriamycin and the possible underlying mechanisms. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 5 | In the present study, we explored whether inhibiting the glucose transporter 1 (GLUT1) could restore the activity of adriamycin in breast cancer cell line MCF-7 resistant to adriamycin and the possible underlying mechanisms. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 6 | Adriamycin-resistant cell line MCF-7/ADR was selected stepwise from the parental MCF-7 cells and the level of GLUT1 was measured. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 7 | Inhibition of the GLUT1 could partially restore the antineoplastic effects of adriamycin in the adriamycin-resistant MCF-7 cell line possibly through activating the AMPK, downregulating the mTOR pathway, and increasing the BAX translocation to mitochondria. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 8 | Inhibition of the GLUT1 could partially restore the antineoplastic effects of adriamycin in the adriamycin-resistant MCF-7 cell line possibly through activating the AMPK, downregulating the mTOR pathway, and increasing the BAX translocation to mitochondria. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |