Pub. Date : 2017 Oct
PMID : 28608236
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | The current study was designed to evaluate the role of CREB-BDNF signaling in mediating the neuroprotective effects of curcumin against nicotine-induced apoptosis, oxidative stress and inflammation in rats. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | In addition, nicotine treatment increased lipid peroxidation and the levels of GSH, IL-1beta, TNF-alpha and Bax, while reducing Bcl-2, P-CREB and BDNF levels in the hippocampus. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | Thus, curcumin via activation of P-CREB/BDNF signaling pathway, confers neuroprotection against nicotine-induced inflammation, apoptosis and oxidative stress. | Nicotine | cAMP responsive element binding protein 1 | Rattus norvegicus |