Title : Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.

Pub. Date : 2017 Aug

PMID : 28605057






2 Functional Relationships(s)
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1 The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity indexes (SI = 4.77-5.43) compared to the reference drug celecoxib (SI = 7.8). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The synthesized compounds showed good selectivity for COX-2; compounds 8a, 8d, 8f, 11a, and 11c exhibited the highest COX-2 selectivity indexes (SI = 4.77-5.43) compared to the reference drug celecoxib (SI = 7.8). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens