Title : Metal-free formal carbon-halogen bond insertion: facile syntheses of 3-halo 3,3'-disubstituted oxindoles and spirooxindole-γ-butyrolactones.

Pub. Date : 2017 Jun 22

PMID : 28604855






1 Functional Relationships(s)
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1 A novel P(NMe2)3-mediated formal carbon-halogen bond insertion of isatins into allylic and benzylic bromides/chlorides has been realized, leading to a facile synthesis of 3-halo 3,3"-disubstituted oxindoles. Bromides NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens