Title : A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.

Pub. Date : 2017 Jun 30

PMID : 28604389






2 Functional Relationships(s)
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1 Moreover, mechanistic studies showed that the CRL4B-PRC2 complex, under the control of the delta cell-specific transcription factor hematopoietically expressed homeobox (HHEX), determines the levels of intracellular calcium and cAMP through histone posttranslational modifications, thereby altering expression of the Cav1.2 calcium channel and adenylyl cyclase 6 (AC6) and modulating somatostatin secretion. Cyclic AMP hematopoietically expressed homeobox Homo sapiens
2 Moreover, mechanistic studies showed that the CRL4B-PRC2 complex, under the control of the delta cell-specific transcription factor hematopoietically expressed homeobox (HHEX), determines the levels of intracellular calcium and cAMP through histone posttranslational modifications, thereby altering expression of the Cav1.2 calcium channel and adenylyl cyclase 6 (AC6) and modulating somatostatin secretion. Cyclic AMP hematopoietically expressed homeobox Homo sapiens