Title : Photoaffinity labelling of MSH receptors on Anolis melanophores: effects of catecholamines, calcium and forskolin.

Pub. Date : 1985

PMID : 2860247






3 Functional Relationships(s)
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1 The longlasting signal generated by the covalent MSH-receptor complex was readily and reversibly abolished by adrenaline, noradrenaline, dopamine or clonidine or by the absence of calcium. Norepinephrine proopiomelanocortin Homo sapiens
2 Forskolin, which stimulates melanophores by direct action on the catalytic unit of the adenylate cyclase and at about the same speed as alpha-MSH, produced a slower and weaker response in the presence of noradrenaline. Norepinephrine proopiomelanocortin Homo sapiens
3 If MSH receptors were covalently labelled and then exposed to noradrenaline, the characteristics of the forskolin-induced response were identical to those of unlabelled cells that had not been exposed to noradrenaline. Norepinephrine proopiomelanocortin Homo sapiens