Title : Conformational behavior of alpha-2-macroglobulin: Aggregation and inhibition induced by TFE.

Pub. Date : 2017 Nov

PMID : 28600207






5 Functional Relationships(s)
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1 Conformational behavior of alpha-2-macroglobulin: Aggregation and inhibition induced by TFE. Trifluoroethanol alpha-2-macroglobulin Homo sapiens
2 In the present study, we explored how trifluoroethanol (TFE) may modulate the structure, antiproteinase activity and aggregation of alpha2M. Trifluoroethanol alpha-2-macroglobulin Homo sapiens
3 In the present study, we explored how trifluoroethanol (TFE) may modulate the structure, antiproteinase activity and aggregation of alpha2M. Trifluoroethanol alpha-2-macroglobulin Homo sapiens
4 Insignificant ThT fluorescence intensity of TFE treated alpha2M is indicative of amorphous or non-amyloid aggregation. Trifluoroethanol alpha-2-macroglobulin Homo sapiens
5 Our studies provide important mechanistic insight how alpha2M undergoes conformational and functional changes when exposed to TFE. Trifluoroethanol alpha-2-macroglobulin Homo sapiens