Title : The transient manifold structure of the p53 extreme C-terminal domain: insight into disorder, recognition, and binding promiscuity by molecular dynamics simulations.

Pub. Date : 2017 Aug 16

PMID : 28597880






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In its active form p53 is a tetramer, with each monomer organised in domains with different degrees of structural stability, ranging from the well folded DNA-binding domain (DBD) and tetramerization domain (TET), to the intrinsically disordered transactivation domain (TAD), and extreme C-terminal domain (CTD). tet tumor protein p53 Homo sapiens