Title : N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5.

Pub. Date : 2017 Apr

PMID : 28595035






1 Functional Relationships(s)
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1 Inhibiting NMDARs using memantine and ifenprodil alleviated NFH reduction and APP accumulation, decreased Cdk5 expression, and inhibited the activity of GSK-3beta in the white matter of PTZ-kindled rats. Memantine glycogen synthase kinase 3 beta Rattus norvegicus