Title : Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors.

Pub. Date : 2017

PMID : 28594907






3 Functional Relationships(s)
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1 RESULTS: Our results showed that telomerase regulates VEGF expression and secretion through its catalytic subunit hTERT in AGS, Caco2, and HepG2/C3A, independent of its catalytic activity. caco2 vascular endothelial growth factor A Homo sapiens
2 Interestingly, VEGF inhibition with bevacizumab (100mug/ml) increased hTERT expression 42.3% in AGS, 94.1% in Caco2, and 52.5% in HepG2/C3A, and increased telomerase activity 30-fold in AGS, 10.3-fold in Caco2 and 8-fold in HepG2/C3A. caco2 vascular endothelial growth factor A Homo sapiens
3 Interestingly, VEGF inhibition with bevacizumab (100mug/ml) increased hTERT expression 42.3% in AGS, 94.1% in Caco2, and 52.5% in HepG2/C3A, and increased telomerase activity 30-fold in AGS, 10.3-fold in Caco2 and 8-fold in HepG2/C3A. caco2 vascular endothelial growth factor A Homo sapiens