Pub. Date : 2017
PMID : 28580174
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of concomitant inactivation of p53 and pRb on response to doxorubicin treatment in breast cancer cell lines. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | We inactivated TP53 and/or RB1 by siRNA mediated knockdown in breast cancer cell lines varying with respect to ER/PgR and Her-2 status as well as TP53 and RB1 mutation status (MCF-7, T47D, HTB-122 and CRL2324) and determined effects on cell cycle arrest, apoptosis and senescence with or without concomitant treatment with doxorubicin. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | While no significant change was observed for the CRL2324 cells upon doxorubicin treatment, MCF-7, T47D as well as HTB-122 cells responded to knockdown of TP53 and RB1 in concert, with a decrease in the fraction of cells in G1/G0-phase (P=0.042, 0.021 and 0.027, respectively). | Doxorubicin | tumor protein p53 | Homo sapiens |
| 4 | Interestingly, upon doxorubicin treatment, concomitant inactivation of TP53 and RB1 caused a decrease in senescence in MCF-7 cells (P=0.027). | Doxorubicin | tumor protein p53 | Homo sapiens |
| 5 | We found concomitant inactivation of TP53 and RB1 to affect various routes of response to doxorubicin treatment in breast cancer cells. | Doxorubicin | tumor protein p53 | Homo sapiens |