Title : The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome.

Pub. Date : 2017 Jul 21

PMID : 28576828






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1beta, ASC speck formation, and secretion of mature IL-1beta. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1beta, ASC speck formation, and secretion of mature IL-1beta. Adenosine Triphosphate interleukin 1 beta Mus musculus