Title : Lysozyme in water-acetonitrile mixtures: Preferential solvation at the inner edge of excess hydration.

Pub. Date : 2017 Jun 7

PMID : 28576085






5 Functional Relationships(s)
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1 Lysozyme in water-acetonitrile mixtures: Preferential solvation at the inner edge of excess hydration. acetonitrile lysozyme Homo sapiens
2 Organic solvent/water sorption and residual enzyme activity measurements were performed to monitor the preferential solvation/hydration of hen egg-white lysozyme at high and low water content in acetonitrile at 25 C. The obtained results show that the protein destabilization/stabilization depends essentially on the initial hydration level of lysozyme and the water content in acetonitrile. acetonitrile lysozyme Homo sapiens
3 At high water content, the lysozyme has a higher affinity for water than for acetonitrile. acetonitrile lysozyme Homo sapiens
4 At the intermediate water content, the dehydrated lysozyme has a higher affinity for acetonitrile than for water. acetonitrile lysozyme Homo sapiens
5 At low water content, the preferential binding of the acetonitrile molecules to the initially hydrated lysozyme was detected. acetonitrile lysozyme Homo sapiens