Title : Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Pub. Date : 2017

PMID : 28570653






2 Functional Relationships(s)
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1 RESULTS: AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1beta and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-alpha and IL-6 compared to AIT alone. tofacitinib interleukin 6 Homo sapiens
2 Furthermore, TOFA co-administration significantly reduced systemic IL-6, IL-1beta and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone. tofacitinib interleukin 6 Homo sapiens