Title : Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells.

Pub. Date : 2017 May

PMID : 28565807






9 Functional Relationships(s)
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1 Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/beta-catenin signaling pathway in Jurkat cells. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
2 The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
3 The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
4 The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
5 The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless-type MMTV integration site family (WNT) pathway in Jurkat cells. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
6 Following treatment with As2O3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
7 Following treatment with As2O3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
8 These results suggest that As2O3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens
9 These results suggest that As2O3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene. Arsenic Trioxide secreted frizzled related protein 1 Homo sapiens