Pub. Date : 2017 May 30
PMID : 28564604
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On a molecular level, diminished IDH1 activity results in reduced alpha-ketoglutarate (alphaKG) and NADPH production, paralleled by deficient carbon flux from glucose or acetate into lipids, exhaustion of reduced glutathione, increased levels of reactive oxygen species (ROS), and enhanced histone methylation and differentiation marker expression. | NADP | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |